Gazidis, who took up his role at the Gunners in 2009, has been named by the European Club Association (ECA) as their representative on UEFA's primary policy-making body - the UEFA Professional Strategy Council.
He will also take up a place on the ECA Executive board which represents the interests of Europe's top 207 teams.
Gazidis was part of the management team that was in charge of setting up the MLS in 2001 and he will replace Manchester United's CEO, David Gill, on the ECA board.
ECA Chairman Karl-Heinz Rummenigge said: "I am pleased to welcome Ivan Gazidis on the ECA Executive Board. His experience and distinct football knowledge will add a lot of value to ECA and European football as a whole."
Upon his appointment Gazidis said: "I am delighted to be joining these important groups which are hugely influential in the future direction of the game in Europe. I am looking forward to representing the top European clubs in many important debates as we move ahead."