A trip to Fulham follows but Arsenal's third game of the season is the north London derby with Spurs at the Emirates.
Boxing Day's fixture is at West Ham and, on New Year's Day, Arsene Wenger's men will host newly-promoted Cardiff City.
The second match with Tottenham takes place at White Hart Lane on March 15, the first of a run of four potentially huge matches, with Chelsea, Manchester City and Everton to follow.
Arsenal face champions Manchester United away on November 9, and at home on February 11.
Arsenal's run-in looks a good one, with home fixtures against West Ham and Newcastle on April 12 and 26 respectively, and away trips to Hull (April 19), West Brom (May 3) and Norwich on the last day of the season.