The Gunners face a trip to Napoli for their final UEFA Champions League match before returning to face Manchester City at the Etihad Stadium, where the hosts have won every Premier League game this season.
Arsene Wenger's side are five points clear at the top of the Premier League table heading into the festive fixtures following their 1-1 home draw with Everton on Sunday.
The Frenchman, who re-joined Arsenal on a free transfer from AC Milan in the summer, said: "It is a great feeling (to be five points clear), but the championship is long and we still have a lot of teams to play.
"Now it is important just to focus on game after game, because we have another big match away to Napoli, and then play at Manchester City, so everything goes very quick in the championship, especially when you have so many games.
"It is going to be a busy period for us and we just have to focus.
"These are all big games, the ones you want to play in, and everyone is excited to be playing in them".
All attention will now turn to Wednesday's Champions League clash against Napoli, where a draw would be enough to clinch first place in Group F.
Arsenal could lose and still progress depending on the final scoreline at the Stadio San Paolo and Borussia Dortmund's result in Marseille.
Flamini added: "It will be an interesting period for everyone and hopefully a good one for us."