Ashley Barnes headed home the only goal of the game from Michael Kightley's seventh-minute cross in a significant 1-0 win at Barnsley to lift Burnley to within touching distance of a place back in the top flight after a four-year absence.
Should Dyche's side beat Middlesbrough at Turf Moor and third-placed Derby lose at home against Huddersfield, the Lancashire club will be assured of promotion.
"The next game for us is a big one," said Dyche. "We've been focusing on it all season and that won't change.
"Every game we've come across for all different reasons, they're all tough games, so we'll be preparing for it.
"I've already told the players to enjoy tonight, but we're already prepping, recovering already and getting ready for the weekend."
Barnes' early breakthrough was one of few clear-cut chances in a disappointing game, sending Danny Wilson's side second-bottom of the table and dealing their Sky Bet Championship survival chances a huge blow.
It was a routine win in the end for Burnley and lifted them 11 points clear of their nearest rivals with five games left to play.
"The outcome was the main part we were looking for," said Dyche. "To come away from here with a 1-0 victory, a clean sheet and out keeper's not had a save to make.
"I was really pleased with that side of the game, that's for sure.
"It was a very well-worked goal. Barnesy should have probably got a brace to be honest, but his endeavour, his commitment to the cause, his work ethic, he just constantly gets into the right areas.
"It was great play from Michael Kightley and a really good finish. It set us up nicely, but credit to Barnsley, they never stopped, got the ball forward early and can be hard to play against."
Barnsley were a pale shadow of the side which had reignited their relegation fight with successive away wins at Reading and Yeovil in recent weeks.
Boss Danny Wilson accepted defeat made survival all the more difficult, but had not been a terminable blow.
"No, it's not, not at all," he said. "That's a fair assessment.
"We're disappointed, of course we are. Anything we could have taken off the team who are second would have been a real confidence booster for us.
"But we move on to Bolton on Saturday. There is still great belief. There's six games to go, 18 points to play for, which is a lot at this stage.
"We're still in with a chance, it's down to ourselves. It's whether we believe or not that we can push it over the line and I certainly do."