The Seasiders ended a four-month wait for a victory as Ricardo Fuller's 14th-minute header gave them a 1-0 victory over fellow strugglers Millwall, whose boss Ian Holloway suffered defeated again on his return to Bloomfield Road.
It was Holloway who signed Ferguson for Blackpool in the summer of 2011 and the Scot was able to further his own managerial credentials by finally winning at the ninth time of asking.
The 36-year-old praised his players for the commitment and desire they delivered after receiving a short, concise message from their stand-in boss before kick-off.
"All I asked on Monday morning was to go out and be positive, I didn't want any negativity about the place because of the position we've been in for a number of months," Ferguson said.
"The team talk lasted probably about 20 seconds at most. It was just quick and I got everything I asked of them.
"I just said go out and be positive and if you give me everything you've got after the game I'll be a happy man - and they did that today.
"It was one of the worst games I've watched but I couldn't care less; it's three points and it stops the rot."
Ferguson's message to the supporters was slightly longer as he thanked them for their continued support during an 18-match winless run which the Blackpool manager admitted was the most difficult period he has ever known.
There was an outpouring of relief from players and fans alike at the final whistle, and Ferguson added: "Since I've took over the fans have been excellent - when I've passed them in the street, when I've bumped into them.
"Since I've been here they've always been behind me, even when I was playing they were always behind me, even though we were going through a difficult period.
"This is probably the most difficult period I've ever known in football, not just with myself. They were excellent today, they never stopped from the first whistle to the last whistle."
There were plenty of signs that Blackpool's luck would finally turn in the first half as their visitors twice struck the woodwork while Steve Morison's weak penalty, which came moments after Fuller's opener, was saved by Matt Gilks' legs.
"I really liked what I saw at the start," said Holloway, who claimed he may look to bring in another tall striker with Morison picking up a neck injury.
"We hit the bar and I thought it was only a matter of time before we were going to score but that's how it's gone. That's how it's gone for them as well recently."
Holloway has now lost both of the trips he has made to Blackpool since leaving their managerial post, this loss following on from the 1-0 defeat he suffered with Crystal Palace last April.
"I still can't believe it to be perfectly honest with you," Holloway, who took the Seasiders to the Premier League, admitted.
"Last time I came here I lost to 10 men and it feels like deja vu really. But I won enough when I was here so it's swings and roundabouts. Good luck to them."