The 29-year-old started his career with Villa and made 56 appearances for the club before leaving to join Cardiff in 2007.
He has not played a league match at Villa Park since his move, and admits it will be a special occasion as he takes on Paul Lambert's side.
"I came through the youth set-up at Villa," said Whittingham. "They played a massive part in my career and made me the player I am today. It's going to be a great occasion and a match from which we can earn three points.
"Villa have a lot of young players and it will take time. They will make mistakes, but their manager knows what he is doing. He will nurture them and Villa will be okay in the long run.
"It's a massive club with a great history. But our job is to do all we can to win and that's what I am focused on."