The Premier League's bottom two clubs face off at the Cardiff City Stadium with both facing a mountain to climb to avoid relegation this season.
The Bluebirds are just one point ahead of Fulham having won only one of their last 12 league fixtures - last weekend's 1-0 defeat at Tottenham was their fourth straight loss - while Fulham have not tasted victory since New Year's Day.
But despite their poor run, Cardiff are only three points adrift of safety and Solskjaer is very aware of the magnitude of their showdown with the Cottagers.
"It's the biggest game for us," Solskjaer said. "Obviously, this game is massive. You just want your players to go out there, play and express themselves with no fear.
"At this stage of the campaign, you look at the form and confidence and I don't think any of these two teams can say we are in top shape.
"I don't think either side would be happy with a draw. There will be two teams that have to go out there and try to win the game. I think you will see some positive football from both sides.
"But we are at home. We've played some good games at home lately even though the Hull game (a 4-0 loss) was disappointing.
"But we have dominated some games here and we should have scored two or three goals. Hopefully, this time we will get the rewards for all the work we have done."
The main cause of Cardiff's struggles this season has been up front, scoring only 19 goals in 28 games.
The Bluebirds have failed to score in their last four league games and Solskjaer added: "You need goals to take points.
"We need to score goals. To get a win, you need to perform.
"You have to earn the right to win a game by doing the hard work and you have to get the quality there, especially going forward.
"Against Spurs we had so many one-on-one chances against the 'keeper, four times at least we should have been through.
"It's that little bit of extra quality that will get us some points."