It had been hoped the Serbian would make his comeback after knee surgery but Vidic is not keen to rush back after virtually 12 months on the sidelines.
Sir Alex Ferguson is promising changes and Nick Powell could be set for a rare start.
With United already through as Group winners, United have the luxury of being able to blood youngsters like Powell, and Scott Wootton, who already has Champions League experience.
Cluj on the other hand can still qualify for the knockout stages, depending on how Galatasaray fare against Braga in Portugal.
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