The Addicks' seven-match unbeaten run came to an end thanks to two goals from Wanderers' David Ngog.
But they face a trip to struggling Wednesday next weekend before home games against Ipswich and Derby after Christmas.
"We have to move forward and we have to go on a good run again," said Powell.
"The players are disappointed of course but we can learn from it, prepare right again for the next game which is Sheffield Wednesday - and then the busy Christmas period.
"I'll be looking forward to us getting points again and moving forward and bouncing back from a defeat that shouldn't have happened.
"But it has and we just have to be right again and go on a good positive run."