The game in Ukraine will decide the fate of the Blues, who must beat FC Nordsjaelland at Stamford Bridge and hope for a home win for Mircea Lucescu's side, who have already qualified for the last 16.
The Bianconeri, who leapfrogged Chelsea after beating them 3-0 in Turin last month, only need a point to qualify for the next stage of the competition.
But Pirlo is adamanat the Old Lady will look to secure all three points which would hand them top spot in Group E.
He said: "We want to win the group and I am sure Shakhtar do as well.
"Any talk of playing for a draw is not true of any of the players here at Juventus and I am sure it is not true of the Shakhtar players.
"We have no duty to help Chelsea, but we have a duty to ourselves and to our fans to try and win the group.
"You will not get two easy games whoever you face in the last 16."