It follows a pitch inspection in Kazan and comes despite the Russian club insisting their home pitch will be suitable for the meeting on Thursday, April 11.
Rubin's two previous home matches in the knockout stage of this season's Europa League were also in Moscow.
A statement on Chelsea's website said: "Following a pitch inspection in Kazan, UEFA are of the opinion the pitch and climate conditions at the Tsentrainiy Stadium, Rubin Kazan's home ground, cannot guarantee the best possible conditions."
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