Chamakh suffered a hamstring injury in last month's 1-1 draw with Swansea and was forced to sit out a number of crucial games for the south Londoners.
Palace had failed to find the net during his absence until John Terry's own goal gave the Eagles a much-needed 1-0 win over Chelsea last weekend.
Pulis has welcomed Chamakh's return to fitness, but refused to reveal whether the former Arsenal man will be included in the starting line-up.
"Most of them are fit, Chamakh has trained all week with us and he looks ready to go," he said.
"Whether we start him or whether he's involved on the bench, we'll have to wait and see.
"Well he's been outstanding for us. He's been for me the player that gives us a little bit different within the group so we'll see. It's a decision that I'll make most probably closer to the game."
Palace earned plenty of plaudits for their battling win over the Blues, which moved them five points clear of the drop-zone.
But Pulis insists the Eagles will be plunged back into the relegation mire if they let their standards slip in Wales.
"It was three points against Chelsea but that is gone now," he said.
"The most important thing is to focus on the next game, which is probably going to be more difficult. The lads can take a lot from the way they played last weekend but that goes out the window when we kick-off on Saturday.
"All that counts now is the Cardiff game. We need to make sure we put in enough performances like last weekend to get us over the line.
"If people think it is all over and done with after the Chelsea game it isn't, we have still got to get the points because everyone down there is fighting. We have go focus on getting the points as quickly as we can."