Exactly six years ago Miika Koppinen, then at Rosenborg, scored the opening goal of a 1-1 draw which brought Mourinho's three-year stint at Stamford Bridge to an end.
The 35-year-old is back in London again with Tromso and this time he has Villas-Boas' Tottenham in his sights.
Speaking ahead of the Norwegian side's Europa League opener at White Hart Lane, the giant Finnish centre-back told Press Association Sport: "The last time I was here in London it was a nice experience for me.
"Playing in England is like a dream come true for every footballer.
"The culture, the atmosphere, the stadiums, it was a nice experience and I hope we can create something like that again.
"I would love to score against Tottenham. It's going to be difficult.
"Spurs are one of the best teams in England and they are in the top 20 teams in Europe, but anything is possible."
Koppinen is sure that Villas-Boas will not suffer the same fate as Mourinho on Thursday night even if Tromso pull off a shock win.
But the defender knows his experience of upsetting the odds in the English capital could prove handy, and if Tottenham think they are in for a soft ride, then they have another thing coming.
"You have to respect the opponents, but when the whistle goes it's no more nice guys," the Tromso captain said.
"We had lots of experience in Rosenborg. Tromso are a young team apart from a couple of older players like me, so I hope I can just tell the young guys to not concentrate on the games and focus them on believing that anything is possible."
Tottenham fans are used to seeing a Welsh star steal the show at White Hart Lane thanks to Gareth Bale's exploits over the last six years, but it could be the turn of midfielder Josh Pritchard, who is on loan at Tromso from Fulham.
"Josh has been a good player," Koppinen added.
"He struggled at the start, but it was hard for him to step up from Fulham's reserves. Now he has more respect and he is developing well."