The Tigers lost the first leg of their Europa League play-off after a costly error from goalkeeper Allan McGregor allowed Hans Vanaken to chalk up the game’s only goal and claim victory for the Belgian side.
However, Egyptian international Elmohamady insists Hull understand the challenge set before them and admits they can ill-afford another momentary lapse in concentration.
"We know we have to win 2-0 on Thursday night after the first game, but we are confident,” he told the Daily Star.
"We want to keep the fans happy by winning and getting to the group stage, that's our aim.
"When you play in Europe you have to keep your concentration and last week we conceded a goal from nothing.”
After losing in East Flanders, Hull were held to a 1-1 against Stoke after a late Ryan Shawcross equaliser denied Steve Bruce’s side the win.
Despite being reduced to 10 men in the 14th minute Hull displayed fine resolve to hold onto their lead until seven minutes from time and Elmohamady believes they must draw on such togetherness once again as Lokeren arrive in East Yorkshire.
"When you have 10 men against 11 you need every single player to work hard and give everything they have and we had that,” he added.
"All the lads gave everything they had, 150 per cent effort, and if we can keep the performances like this we will go a long way.
"We had a great attitude. Last year the attitude was great and you can see it again this year."