The midfielder netted his maiden Mersey derby strike in October's 2-2 draw at Goodison Park and insisted that the Toffees could secure all three points this time around.
"Scoring would be great," he told the club website. "I'd be delighted if I could get another goal, especially at Anfield, but the points are more important to us."
Victory would mean ending a 13-year hoodoo on the other side of Stanley Park, with Kevin Campbell's strike in September 1999 earning Everton's last Anfield win.
But Osman believes the time is right for the run to end and added: "It's certainly something we need to put right.
"It's a long time since we've gone over there and come back with three points. It's a place we need to go to and win. We've shown we can win at Goodison Park, but we want to go there and do the same.
"It's a game like any other. We'll go there full of the confidence that we've got this year.
"We're five points above them at the minute and a win would certainly be great for us but we're still on the coat-tails of the teams above us and we're trying to win for that reason as well."