Roberto Mancini's side are seeking FA Cup success for the second time in three years after beating their opponents 1-0 in the 2011 final.
Midfielder James Milner said: "It should be a really good old fashioned FA Cup tie but we're confident, going there on the back of five straight wins.
"The Britannia Stadium is not the easiest of venues to go to but if we can quieten the home crowd early on then so much the better.
"The fact that we're taking more than 4,000 fans is really important because the Stoke fans make a lot of noise, but our supporters are brilliant and will give as good as they get when it comes to creating an atmosphere."
Stoke boss Tony Pulis is also aware of how big a role the fans can make in the outcome of the match.
"We have to play to our maximum, and the crowd have to be at their maximum, for us to get a result on Saturday."