Having sold out their allocation of tickets, Hull will compete in their first final in the competition after retaining their Premier League status earlier in the month.
Following Wigan's shock win over Manchester City in the 2013 final, Bruce is hoping his side will spring a similar surprise this weekend by beating the Gunners.
"If you're not an Arsenal fan, I'm sure the rest of the world will be rooting for Hull," he is quoted in the Daily Star.
"Last year, we saw Wigan beat City, who were huge favourites. Everybody enjoys a shock and we are rank outsiders but that's the beauty of the FA Cup - it can bring a lot of glamour."
He added: "The memories of the FA Cup are ones you cherish when you have finished your career. That's why, for me, it is the greatest competition. It's a one-off game and a place where heroes are made.
"For a club like ours to take on the mighty Arsenal, it just has a fantastic ring to it. That's what the Cup is all about."
Ahead of the clash, the former Sunderland boss insists he will try to savour the occasion in the wake of numerous managerial dismissals this season.
"I've been fortunate enough to win it as a player but to go there as a manager - there have been times when I didn't think that was possible," he said.
"So I'm going to take a deep breath and enjoy the occasion.
"Two or three managers have lost their jobs in the past 48 hours so you've got to try to enjoy the good times.
"And there can't be many better than what we're about to go through."