Vaughan became the Premier League's youngest-ever scorer when he netted for Everton against Palace in 2005, before going on to have a loan spell with the Eagles.
He is currently out on loan again, this time from Norwich, and has impressed at Huddersfield, scoring four goals in what has been an injury-hit spell.
Time on the treatment table is nothing new for the 24-year-old, though, with his career blighted by it.
He is fit for Saturday's game, however, and knows that his current club, without a win in six, must come first.
"I have got a lot of connections with Crystal Palace," he said. "I have been on loan there a few times and it is a club that I have got a lot of time for.
"My time at Palace was really good and the club helped me mature massively as a player. I was playing week in week out. We were battling at the wrong end of the table and it was tough, but we managed to stay up.
"It was a fantastic experience and I met a lot of great people. The fans were always brilliant with me and it is a club that I hold in high regard.
"I am not nervous about playing them on Saturday. I am looking forward to the occasion. It is a tough situation for me personally because I really like Palace, but it is my job to help Huddersfield Town gain three points. For one day only I will be rooting against them."
The last thing the Terriers need is to run into an in-form striker but, in the shape of Palace's Glenn Murray, they will.
The former Brighton man has scored 20 goals this season already and has been catching the eye of almost every Championship observer.
"From what I've been told, it looks like the fittest he's ever been," Keith Millen, who took the job as Ian Holloway's number two last month, told the Advertiser.
"He's just a clever forward, who knows where to be at the right place at the right time and knows when to make the right runs.
"He's a good target man and I've never seen someone that puts centre-halves off when the ball is coming up to him. If he can't get hold of it, it's not often that the defenders get a good header on it.
"He gets on with work in training and looks after himself. He's very professional and he knows what he needs to do to stay right."
Playing so well comes at a price, though, and Millen has told Murray to show any interested parties what he can do when the cameras are on him today.
Millen said: "Playing on television, it puts you in the shop window and it's good for the players to be seen and go out there to show what they can do. The lads are looking forward to it, although it will be a tough game because if you look at their team, it's strong - it won't be easy."