Steve Bruce's men, who secured second place on the last day of the 2012/13 Championship season, will visit Chelsea before hosting Norwich, then a daunting trip to former Premier League champions Manchester City awaits.
Home games against Cardiff and West Ham follow in September, with a visit to Newcastle in between.
Hull will then face Tottenham, Everton and Aston Villa during a testing October.
The Premier League new boys will then host Liverpool on 30 November before facing a trip to London to face Arsenal just three days later.
Bruce's side then play his former club Manchester United on Boxing Day, with a tough Christmas period continuing with a trip to Anfield as Liverpool play host to kick off 2014.
Their final six games include visits to Manchester United, Fulham and Aston Villa, while Swansea and Arsenal travel to Hull before a final game of the season clash against Everton at the KC Stadium.