The Swansea striker has made a massive impact in his first season in England, and his 13th league goal of the season against Manchester United on Sunday put him on top of the scoring charts at Christmas.
Michu cost Swansea only just over £2million and has proved to be a real bargain buy, his form helping the Swans into a comfortable mid-table position.
Spain face Uruguay in a friendly in Doha on February 6 and their coach Vicente del Bosque said: "Michu and Iago Aspas will appear."
Celta Vigo striker Aspas has also been linked with a move to Swansea in the press, although an asking price of more than £8million could prove to be a stumbling block.
Aspas has been with Celta since his early days in their youth set-up and was instrumental in getting them promoted to La Liga last season with 23 goals - he has added six more in 12 top-flight outings in 2012-13.