Early goals from Darren Potter and Daniel Powell set Milton Keynes on the way to victory before a second-half penalty from Jamal Campbell-Ryce gave County hope of a comeback, but the game finished 2-1.
"The players are disappointed as we have lost at home again and we don't like to lose and we need to get that resolve we have away from home," said Curle after his side's sixth league loss of the season at Meadow Lane.
"We gave ourselves a mountain to climb. They probably only had three shots in the first half and scored from two of them.
"I still thought we would get back into it as we were putting lots of balls into their box and in the second half we were creating some clear-cut opportunities that we couldn't take.
"Even at 2-1 I thought there was only one team that was going to win - and that was us. We totally dominated the second half but didn't take our opportunities."
Curle said he will look into why his team had started the game so lethargically despite meticulous preparation.
He added: "We will have a look at all the preparation and the planning that we did in the build-up to the game and analyse that as we are notoriously good starters in games. Sometimes it can be the smallest thing that is wrong."