Grant Basey, Dennis Oli, Olly Taylor and Georges Ehui will head to pastures new while further meetings with the Blues' out of contract players will take place in the coming days.
Basey played just four times in an injury-hit season while Oli, who also suffered from injury problems, featured just six appearances under Gareth Ainsworth.
Youngsters Taylor, who played six times for the Chairboys, and Ehui will also leave.
Lee Angol and Max Kretzschmar have been offered new contracts while the club has taken up its option to keep Junior Morias until the end of next season.
The 17-year-old attacker has become a fans' favourite with his performances as an impact substitute while Angol and Kretzschmar are yet to feature under Ainsworth but are highly thought of.