Injuries to the likes of Daniel Agger, Kolo Toure, Glen Johnson and Jose Enrique at various stages of the season have resulted in a shake-up in defensive personnel.
Brendan Rodgers' side have lost only three league matches and are scoring a lot of goals, particularly at home, but have only kept one clean sheet in the last dozen games.
"All the players who are there are professional enough to deal with that," said the Belgium international, who has enjoyed an impressive start to his Anfield career since arriving from Sunderland in the summer.
"All the defenders here are very organised, motivated and concentrated.
"We need to do a job. It doesn't matter as a keeper who is in front of me.
"I work day in, day out with the lads. I know what they can do and it doesn't affect me whether the defenders change."
Mignolet would obviously like to improve his personal record but insists that is not the priority.
"You want to keep clean sheets - that is what I am there for - but you are just one part of the team," he added.
"It's what you look forward to before a game starts but if we keep winning 4-1 until the end of the season I'll be a happy chappy.
"The most important thing is to try to win the game."