The Potters boss was sacked by City's current hierarchy in December 2009 despite a respectable record at the Etihad Stadium, to be replaced by a higher-profile manager in Roberto Mancini.
Spells at Fulham and QPR came and went without notable success before the Welshman took the reins at the Britannia Stadium.
His tenure began with a narrow defeat by Liverpool in the Barclays Premier League opener but wins over West Ham and Crystal Palace have ensured life in Staffordshire has begun on a positive note.
And the 49-year-old maintains he has no reason to seek revenge when his old club come to town this weekend.
"I enjoyed my time at Manchester City," he said. "Yes, it was difficult as it was a big time of change for the club, but I think I can look back upon my time there and be pleased with what we achieved.
"The season that I got the sack we had lost two games in 17, so it wasn't too bad.
"The owners wanted to make a change and bring in their own man, though, and that is football I guess."
Hughes has more pressing priorities than getting one over on City as he instead concentrates on moulding Stoke into the side he wants.
The Potters were traditionally seen as a long-ball side under his predecessor Tony Pulis but fans have already noted the change in philosophy under the former Manchester United forward.
"We are building quickly as a team and I think the performance at West Ham showed this," he said.
"We have points on the board early which is good and I've been pleased with what we've been producing on both the training field and on the pitch on a matchday.
"I do think we'll improve further though as the season goes along.
"I want the players to pass the ball quickly and move up the pitch that way, but if there are opportunities of getting the ball forward quickly, we'd be foolish not to use those assets as well."
The Welshman added: "The players have shown tremendous work ethic and their attitude to everything that myself and staff have asked of them has been first class.
"They are a great bunch of players to work with.
"The international break probably came at the wrong time for us, but Manchester City may say the same too, as they have lost a couple of players through injury.
"We're on a good run as I said before and ideally we would have played this game straight after West Ham.
"We're prepared though and we are ready to give them a real good game tomorrow."