City host the Catalans at the Etihad on Tuesday in the eagerly-awaited first leg of their last 16 UEFA Champions League clash.
Former Manchester United defender Pique is looking forward to his return to England and insists Barcelona are not just reliant on Argentinean wizard Messi, with players of the calibre of Brazilian striker Neymar as well as Pedro and Alexis Sanchez in the team.
Pique told the Daily Telegraph: "He's (Neymar's) really young, he's got a lot of hunger to show to the world that he is right for Barcelona and that he's one of the best players in the word.
"His quality, his skills, his goals, have added a lot to the team and at the same time maybe he takes a little bit of the focus.
"Everything was on Messi, with everyone trying to stop him. Now we have another way. Ok, if it's not Messi's day, we have Neymar, we have Pedro, we have Alexis, we have a lot of quality in the striker area, and I think that's really good for the team."
While Pique believes Barcelona are strong, he is not underestimating the threat from the free-scoring City side managed by former Malaga and Real Madrid boss Manuel Pellegrini.
He added: "Pellegrini always liked to play like this. I remember when he was here in Spain with Malaga and Real before he always liked to play.
"I knew when he signed for City he would try to play like this. I think he has good quality players with David Silva, Kun Aguero - you know, they can have the ball, have the possession.
"They're having a good season."