The 26-year-old midfielder has been linked with a move away from Lazio this summer after producing a series of impressive performances in Serie A last season.
Napoli have been credited with an interest, while speculation had suggested that Manchester United may turn their attention to Candreva after missing out on Thiago Alcantara to Bayern Munich.
However, Lazio have insisted they have no intention of losing any of their key players, as they look to go into the new campaign with a stronger squad than last term.
Asked about Candreva at a press conference, Lotito said: "He's not for sale.
"Napoli? They have never called me, but if they do, I'd say he's not for sale."
Lotito added: "Lazio are the only club who have bought players without selling.
"We wanted to strengthen the team again. I can also say that we have achieved all the market targets we had."