Having graduated out of United's youth system, Welbeck has grown up relishing North West derby dates.
Fireworks are expected again this weekend, with both sides having made impressive starts to the 2013/14 campaign.
Both David Moyes and Brendan Rodgers will also have in-form frontmen available to them at Anfield, with Welbeck hoping he can outshine England colleague Daniel Sturridge in the scoring stakes.
He told United's official website: "I was with Sturridge at a Nike event and we were speaking about our goals, so I'm looking forward to playing against him at Anfield.
"I can't wait for the game. Ever since I've been at the club, coming through the U9s to 15s, 16s, youth team and reserves; no matter what the situation is, it's massive.
"Obviously we'll want to go there and win but it's going to be another intense game and I think the whole club is really looking forward to it."
Welbeck is also looking for United to offer more of an attacking threat on Merseyside than they did during a goalless draw with Chelsea on Monday.
He added: "There was a bit of disappointment because we were at Old Trafford and we really want to be winning our home games.
"But in this league every point is hard to get. Their aim was to keep the goals out and they did that. It was a really tough match and both sides did well.
"It was just a shame that it came two games in - you'd rather it was played further into the season, when it would have been a bigger occasion."