Hyypia's men will travel to Old Trafford to begin their continental campaign, and the German club's personnel appear to be in a bellicose mood, with the boss, and club captain Simon Rolfes, talking up their chances against the Premier League giants.
The Werkself finished third in last term's Bundesliga, and are not without European pedigree, having won the UEFA Cup (now Europa League) in 1987/88, while also finishing as the 2001/02 Champions League runners-up.
Bayer should therefore feel they are strong enough to compete with the Red Devils, and Hyypia, who faced the European juggernauts on numerous occasions during his time as a Liverpool player, wants his side to stay level headed and avoid feeling star-struck.
"On Tuesday evening, we will be ready," Hyypia told reporters. "I hope my players want to play football, and not get autographs from Rooney."
Germany international Rolfes, meanwhile, lacked his manager's sense of levity, but still assured the press his side will not be intimidated by the fanatical support of United's fans.
"We are not afraid of the atmosphere at Old Trafford," the captain insisted. "We have played in front of 80,000 against Dortmund."
Hyypia also commented on new United manager David Moyes.
"David Moyes is an experienced manager," said Hyypia. "Everyone should give him more time to get things running.
"Hopefully it doesn't happen against us. We have to stop them getting their rhythm and make sure they don't score in open play.
"Then we need to be very aware at set pieces."
By Rooney's autograph he means a big X scrawled in crayon surely?- varicoseregent