The 19-year-old West Ham defender has joined on a one-month loan deal but is likely to have to settle for a place on the bench.
That means captain Cliff Byrne will continue to partner Rob Jones at the heart of the defence in the continued absence of David Mirfin who is struggling with an ankle problem.
Other than Spence's potential inclusion, manager Nigel Adkins is expected to name the same side as the one that beat Derby 3-2 at the weekend, meaning Michael O'Connor will continue to fend off the challenge of Grant McCann for a starting berth in central midfield.
United picked up their first points of the season against the Rams and will be looking to add to their haul when they take on Boro for the first time since 1967.
