Vidic suffered an ankle injury during the warm-up to a pre-season game in Munich last month but has trained without a problem for the last 10 days and will take his place in a central defence that will miss Rio Ferdinand (thigh) for another three to four weeks.
Gary Neville could also be involved from the start at the DW Stadium, although most attention will be focused on Dimitar Berbatov and Michael Owen, who are both still searching for their first goals of the current campaign.
United (from): Foster, Kuszczak, O'Shea, Neville, Brown, Evans, Vidic, Evra, Fabio, Valencia, Park, Fletcher, Anderson, Giggs, Scholes, Carrick, Gibson, Nani, Rooney, Berbatov, Owen, Macheda, Welbeck.
