Fabregas has failed to recover from his hamstring injury in time for the Old Trafford showdown but the Gunners have no fresh injury concerns following Wednesday night's 3-1 victory over Celtic.
Theo Walcott (back), Lukasz Fabianski (knee), Samir Nasri (broken leg) and Johan Djourou (knee) all continue their rehabilitation.
Aaron Ramsey is expected to take his place in the squad despite going off with an injury during Wednesday's clash with Celtic.
Arsenal: Almunia, Sagna, Vermaelen, Gallas, Clichy, Song, Ramsey, Denilson, Diaby, Bendtner, Eduardo, Mannone, Van Persie, Eboue, Arshavin, Wilshere, Gibbs, Silvestre, Merida.
