Duguid - who can also play in defence - missed the 3-1 home defeat by Sheffield Wednesday after suffering an ankle injury in the 2-1 defeat at Derby.
Right-back David McNamee also picked up an ankle injury against the Rams, but he too has recovered and is likely to return to Paul Sturrock's squad.
On-loan Cardiff defender Darcy Blake replaced McNamee against Wednesday.
Blake suffered a slight hamstring strain while on international duty but he is also expected to be fit for selection on Saturday.
Argyle are expected to recall Hungarian international central defender Krisztian Timar or start Benin international Reda Johnson in place of Marcel Seip, who was transfer listed this week for a "breach of discipline."