The on-loan Reading stopper was sent off in the early stages of Yeovil's 2-2 home draw with Stockport last weekend.
Richard Martin took over between the sticks and will deputise for McCarthy at St Mary's.
Gavin Tomlin is likely to continue in attack after marking his return to the side against the Hatters with a goal.
Fellow forward Sam Williams is also available following a hip injury.
Williams was initially named among the substitutes on Saturday but came off the bench to grab Yeovil's equaliser - his first goal for the club.
Yeovil currently lie 17th in League One, having won only one of their opening seven fixtures.