Striker Stuart Fleetwood, who started the 2-1 win over Tranmere, is on a season-long loan at Exeter from Charlton but a clause in the deal means he cannot play against his parent club.
Striker Adam Stansfield, who started alongside Fleetwood last Saturday, is set to retain his place.
With all but forward Craig McAllister (thigh) available, Tisdale employed a 4-4-2 home formation against Rovers, recalling Stansfield at the expense of attacking midfielder Liam Sercombe.
Tisdale, however, is never predictable and with a near full strength squad from which to select, he could rejig things at Charlton in a bid to extend Exeter's unbeaten run to three matches.
On-loan Tottenham Hotspur keeper Oscar Jansson is set to continue in goal as first choice keeper Paul Jones is still sidelined by a knee injury.