Semedo has missed the last two games with a pelvic problem, with Matt Spring stepping into central midfield.
The Addicks have no new injury concerns to contend with, but boss Phil Parkinson could tinker with his starting line-up after their unbeaten record shuddered to a halt with a 3-0 defeat at Colchester on Tuesday night.
Sam Sodje came on for a below-par Miguel Llera in central defence and could be in line for his full debut, while Izale McLeod is pushing for a start in attack after some lively cameos from the bench.
Right-back Frazer Richardson returns to the club for whom he made 173 appearances over seven seasons before leaving in the summer.
