Walters came off late on during the 1-1 draw with Watford on Tuesday night which extended Town's winless start to the season to 13 games.
Walters is having treatment for a sprained ankle but could miss out, with Jon Stead and Tamas Priskin lined up to replace him in the starting line-up.
Keane is also without 16-year-old forward Connor Wickham, who will be away with the England Under-17 squad for the next fortnight.
Midfielder David Norris remains sidelined with his serious knee injury, while Argentinian winger Luciano Civelli is also yet to feature this season as he recovers from his knee ligament damage.
Alex Bruce is fit after a groin problem while former England goalkeeper Richard Wright will hope to make his way back into the matchday squad.