Jon Otsemobor, Michael Spillane (both hamstring) and George Francomb (thigh) are all on the sidelines and manager Paul Lambert could not bring in a loan player in time.
Midfielder Stephen Hughes and striker Luke Daley (both thigh) are also out while Michael Nelson and Owain Tudur-Jones lack match fitness.
Centre-half Michael Nelson could start after making an unexpected return from a foot injury as a last-minute substitute in the 1-0 win over Swindon.
Matt Gill was on the bench last week for first time in two months after a knee injury and will be in contention to start after playing for the reserves.
Adam Drury is in line to make his 300th appearance for the club.