Huddersfield have now scored 20 goals in their last four home matches. The promotion chasing Terriers put six past Dagenham last week in the FA Cup and before that both Leyton Orient and Exeter had been dispatched 4-0 in successive league matches.
Peter Clarke headed Huddersfield into a 21st-minute lead when he powered home a cross from Gary Roberts, who then rounded off a sweeping move to make it 2-0 seven minutes later.
Jordan Rhodes had earlier headed straight at Wycombe goalkeeper Jamie Young and Peter Clarke hit the post with another header.
Rampant Huddersfield extended their lead four minutes after half-time when Rhodes teed up Anthony Pilkington, who fired home from the edge of the penalty area.
Rhodes headed against the post and Young saved brilliantly to deny substitute Theo Robinson, but the visiting goalkeeper was beaten for a fourth time when Peter Clarke forced home a rebound.
Robinson spurned two gilt-edged chances soon afterwards, but Michael Duberry deflected a cross passed his own goalkeeper and Robinson finally converted, from the penalty spot, after Roberts had been tripped in the box.