Fletcher returns from a one-match suspension, having sat out the 2-1 win over Doncaster in their last outing before the international break.
Argyle boss Paul Sturrock does wait on the fitness of other key players, though, including wingers Alan Judge (knee) and Craig Noone (foot).
On-loan Blackburn ace Judge was substituted after scoring in the Doncaster success.
Noone - who featured as a substitute against Rovers - was substituted during Tuesday's 1-0 reserves defeat by Swansea and faces a race to be fit.
Argyle also wait on the fitness of on-loan Manchester United right-back David Gray (hip).