The experienced midfielder missed last weekend's draw at Bradford due to a gashed shin and is rated 50/50 for the trip to Moss Rose.
Igoe is also not fully recovered from a knee problem and with the games coming thick and fast in the next couple of weeks, Howe could opt to stick with an unchanged starting line-up with Marvin Bartley keeping his shirt.
Joe Partington returned to the bench after a lay-off with a groin injury last weekend and despite not being fully fit, the midfielder will be in the squad once again.
Josh McQuoid is back in contention after being away on international duty with Northern Ireland last weekend.
Mark Molesley (foot), Shaun Cooper (hip) and Scott Guyett are all unavailable.