The O's got back to winning ways with a 2-1 success over Tranmere on Saturday and Williams has reported no major injury problems ahead of the Elland Road tussle.
"We've just got a couple of niggles and a couple of players have sat out training, and we'll have to wait and see if they come through," he said.
Experienced striker Scott McGleish will keep his place in attack after scoring both goals at the weekend.
Midfielders Adam Chambers and Jason Demetriou will hope to be involved having been unused substitutes against Rovers.
Williams has kept faith with goalkeeper Glenn Morris recently despite the return to fitness of Jamie Jones following a head injury.