Murphy picked up his fifth yellow card of the season in Wednesday night's 1-1 draw at Barnsley so on-loan Josh Lillis will deputise.
Midfielders Martyn Woolford (cut foot) and Michael O'Connor (dead leg) missed the game at Oakwell and remain doubts. Garry Thompson and Sam Togwell could keep their places after performing admirably in their absence.
Defenders Marcus Williams (concussion) and George Friend (facial injury) were substituted during the Barnsley match so Andrew Wright could stand in at left-back.
Ben May (ankle) and Kenny Milne (knee) remain absent.
It is the first time these two sides have met at the Madejski Stadium since 1999 when points were shared in a 1-1 draw.