Gray missed the weekend defeat to Swansea due to a virus, but caretaker manager Sean McAuley could put the former Sunderland left-back straight back in against leaders Newcastle.
The Owls have failed to score in their last six league games - they have lost their last five - and McAuley is expected to make several changes for his second match in charge.
Francis Jeffers was a half-time substitute against Swansea and could return to the starting line-up if McAuley opts to shake-up his forward line, while Frank Simek and Tom Soares, on loan from Stoke, are hoping to play bigger roles.
Wednesday, chasing their first league win in 11 matches, have no suspension troubles, but midfielder Tommy Miller is still out with a hamstring problem.
