Monkhouse, who scored Pools' equaliser in last weekend's 1-1 draw at home to Yeovil, was booked for the fifth time this season in that game and is ruled out against his hometown club.
However, manager Chris Turner hopes to have full-back Neil Austin available after a hamstring problem, meaning Antony Sweeney would be able to stand in for Monkhouse.
Ben Clark is available after completing a one-match suspension for his dismissal at Southend.
Colin Larkin returned to training this week after a hamstring injury of his own but he is unlikely to feature, while Steve Haslam is also edging closer to fitness after a hernia problem but the Leeds game may come too soon.
Striker Denis Behan is around a fortnight away from a return to training, but James Brown (knee) remains a long-term absentee.