Lisbie was recalled from his season-long loan by Ipswich earlier this month but is now back with the U's, and former Luton and Northampton frontman Henderson will be included for the first time after joining on a free transfer last week.
Defender John White is fit despite coming off with a knee injury during the 7-0 FA Cup drubbing at Preston, but midfielder John-Joe O'Toole is still suspended.
A proposed loan move for Cardiff midfielder Solomon Taiwo has been put on hold until next week.
Ashley Vincent (ankle), Lee Beevers (shoulder) and Scott Vernon (knee) are all back in training after spells on the sidelines.
Relations between the clubs are strained after Paul Lambert quit as Colchester manager to join Norwich earlier this season, with compensation yet to be resolved.