Clough will go head-to-head will Billy Davies as the Scot returns to Pride Park for the first time since parting ways with County back in November 2007, however their need for points could not be more different.
Forest will be looking to move level with leaders Newcastle while the Rams will merely be looking to put precious breathing space between themselves and the bottom three.
DJ Campbell returned to start Tuesday's 1-0 defeat at Plymouth and he is in line to make the final appearance of his loan spell against Forest, although Clough is currently in talks with parent club Leicester about extending his stay.
Rob Hulse is certain to start in attack after his impressive display at Home Park, but whether Campbell gets the nod alongside him from the off remains to be seen.
January arrival Russell Anderson is again ready and waiting for his first start since joining the club but Miles Addison (foot), Lee Croft, Lee Hendrie (both hamstring) and Dean Leacock (knee) remain sidelined.