Khizanishvili was an unused substitute during the midweek defeat at Sheffield United but may come in as Brian McDermott celebrates his first game since being confirmed as full-time boss.
McDermott has no new injury concerns ahead of the game and needs three points to lift the Royals closer to safety.
Reading are five points adrift of 21st-placed Sheffield Wednesday and McDermott has 20 games to save the club from relegation to League One.
Noel Hunt, Chris Armstrong and Julian Kelly remain the only injury worries.
Hunt and Armstrong continue to recover from knee surgery while full-back Kelly is out with a shoulder injury.