The left-back injured his thigh during the 2-1 win at Walsall in midweek and is expected to be out for several weeks.
Michael Rose could come in for an instant debut in Drury's place after signing on loan from Stockport until the end of the season.
Captain Grant Holt sits out the second of a three-match ban after his recent red card against Brentford so Oli Johnson will continue to partner Chris Martin in attack.
Martin, 21, took his tally to 17 for the season at Walsall as Paul Lambert's side made it a remarkable 41 points from a possible 45 as they opened up a three-point lead at the top of League One.
Michael Spillane (hamstring) and Jens Berthel Askou (foot) remain sidelined.