Midfielder Leigertwood starts a three-match ban for his straight red card during Saturday's 1-0 defeat at Peterborough and defender Ramage, who was sent off for a second booking, sits out one game.
Akos Buzsaky or Hogan Ephraim could return to the midfield while Matt Connolly will move across to right-back with Damion Stewart recalled to the back four.
On-loan Tottenham forward Adel Taarabt did not travel to London Road and could be added to the squad, while Arsenal loanee Jay Simpson will push to start in attack after coming on as a substitute.
Midfield pair Martin Rowlands and Gavin Mahon are long-term absentees with knee injuries.
