Defender Coloccini missed both the 5-1 victory over Cardiff and the 3-0 defeat at Derby with a hamstring injury, but has been declared fit for the game at the Liberty Stadium.
Ryan Taylor also sat out the game at Pride Park with a similar problem, but he should be available once again as Chris Hughton's men look to bounce back from a first league defeat in 16 games and one which saw them slip from the top of the table.
But left-back Jose Enrique, who damaged a hamstring during the 2-0 victory over Crystal Palace on January 27, is still out, as is Nicky Butt, who has missed the last two games with a thigh injury.
